Kaguyahime (manga), by Reiko Shimizu
On Kabuchi-jima, an island ruled by Princess Kaguya, ten children were raised in an orphanage as sacrificial victims. While they were still on that island, Akira, Yui, and Midori became good friends. They accomplished a death-defying escape and went on to lead separate lives… until the other children who escaped with them started to die mysteriously when getting 16. The remaining children return to Kabuchi-jima through a camp run by an underground American military base and try to disclose the terrible mystery.
